/* Specialty Peptide Index — clinical reference stylesheet */
:root {
  --bg: #FFFFFF;
  --surface: #F4F6F9;
  --primary: #003B7A;
  --primary-hover: #0052a8;
  --accent: #2A2D34;
  --text: #0F1419;
  --muted: #6C7480;
  --border: #E4E7EB;
  --border-strong: #C9CFD6;
  --code-bg: #F4F6F9;
  --warning-bg: #FFF8E6;
  --max-w: 1100px;
}

* { box-sizing: border-box; }

html { -webkit-text-size-adjust: 100%; }

body {
  margin: 0;
  background: var(--bg);
  color: var(--text);
  font-family: 'IBM Plex Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', sans-serif;
  font-weight: 400;
  font-size: 16px;
  line-height: 1.6;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

a { color: var(--primary); text-decoration: none; border-bottom: 1px solid rgba(0,59,122,0.3); }
a:hover { color: var(--primary-hover); border-bottom-color: var(--primary-hover); }

p { margin: 0 0 1em 0; }

code, .mono, .data-label, .data-value {
  font-family: 'IBM Plex Mono', ui-monospace, 'SF Mono', Menlo, monospace;
}

/* ---------- Header ---------- */
.site-header {
  border-bottom: 1px solid var(--border);
  background: var(--bg);
  position: sticky;
  top: 0;
  z-index: 50;
}
.site-header-inner {
  max-width: var(--max-w);
  margin: 0 auto;
  padding: 14px 24px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 24px;
}
.brand {
  display: flex;
  align-items: center;
  gap: 12px;
  color: var(--text);
  border-bottom: none;
  font-weight: 600;
}
.brand:hover { color: var(--primary); border-bottom: none; }
.brand svg { color: var(--primary); flex-shrink: 0; }
.brand-text { display: flex; flex-direction: column; line-height: 1.15; }
.brand-name { font-size: 15px; font-weight: 600; letter-spacing: 0.01em; }
.brand-sub { font-family: 'IBM Plex Mono', monospace; font-size: 10px; color: var(--muted); text-transform: uppercase; letter-spacing: 0.08em; margin-top: 2px;}

.site-nav {
  display: flex;
  gap: 22px;
  align-items: center;
}
.site-nav a {
  font-size: 14px;
  color: var(--text);
  border-bottom: none;
  font-weight: 400;
}
.site-nav a:hover { color: var(--primary); }
.site-nav a.active { color: var(--primary); font-weight: 600; }

.nav-toggle {
  display: none;
  background: none;
  border: 1px solid var(--border);
  padding: 6px 10px;
  font-family: inherit;
  font-size: 13px;
  cursor: pointer;
  color: var(--text);
}

@media (max-width: 760px) {
  .site-nav { display: none; flex-direction: column; align-items: flex-start; position: absolute; top: 100%; left: 0; right: 0; background: var(--bg); border-bottom: 1px solid var(--border); padding: 16px 24px; gap: 12px;}
  .site-nav.open { display: flex; }
  .nav-toggle { display: inline-block; }
}

/* ---------- Layout ---------- */
.wrap {
  max-width: var(--max-w);
  margin: 0 auto;
  padding: 0 24px;
}

.wrap-narrow {
  max-width: 760px;
  margin: 0 auto;
  padding: 0 24px;
}

main { padding: 40px 0 80px; }

/* ---------- Eyebrow / Tags ---------- */
.eyebrow {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 11px;
  text-transform: uppercase;
  letter-spacing: 0.12em;
  color: var(--primary);
  font-weight: 500;
  margin-bottom: 8px;
}

.tag {
  display: inline-block;
  font-family: 'IBM Plex Mono', monospace;
  font-size: 11px;
  letter-spacing: 0.06em;
  padding: 2px 8px;
  border: 1px solid var(--border-strong);
  color: var(--accent);
  background: var(--surface);
}

/* ---------- Headings ---------- */
h1, h2, h3, h4 {
  font-family: 'IBM Plex Sans', sans-serif;
  color: var(--primary);
  letter-spacing: -0.005em;
  line-height: 1.25;
  margin: 0 0 0.5em 0;
}
h1 { font-size: 38px; font-weight: 700; }
h2 { font-size: 24px; font-weight: 600; margin-top: 2em; }
h3 { font-size: 18px; font-weight: 600; color: var(--text); margin-top: 1.5em; }

@media (max-width: 600px) {
  h1 { font-size: 28px; }
  h2 { font-size: 20px; }
}

/* ---------- Hero (home) ---------- */
.hero {
  border-bottom: 1px solid var(--border);
  padding: 56px 0 48px;
}
.hero-grid {
  display: grid;
  grid-template-columns: 2fr 1fr;
  gap: 48px;
  align-items: start;
}
.hero h1 {
  font-size: 44px;
  margin-bottom: 16px;
  letter-spacing: -0.015em;
}
.hero .lede {
  font-size: 18px;
  color: var(--text);
  max-width: 60ch;
  margin-bottom: 0;
}
.hero-meta {
  border-left: 2px solid var(--primary);
  padding: 4px 0 4px 16px;
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--muted);
  line-height: 1.8;
}
.hero-meta strong { color: var(--text); font-weight: 500; }
@media (max-width: 760px) {
  .hero-grid { grid-template-columns: 1fr; gap: 24px; }
  .hero h1 { font-size: 30px; }
}

/* ---------- Section heading ---------- */
.section-title {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  border-bottom: 1px solid var(--border);
  padding-bottom: 8px;
  margin-bottom: 24px;
  margin-top: 56px;
}
.section-title h2 { margin: 0; font-size: 16px; text-transform: uppercase; letter-spacing: 0.08em; color: var(--primary); font-weight: 600; }
.section-title .section-num {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--muted);
}

/* ---------- Index list (homepage) ---------- */
.index-list {
  list-style: none;
  padding: 0;
  margin: 0;
  border-top: 1px solid var(--border);
}
.index-list li {
  border-bottom: 1px solid var(--border);
}
.index-entry {
  display: grid;
  grid-template-columns: 60px 1fr 220px 80px;
  gap: 20px;
  padding: 18px 8px;
  align-items: baseline;
  color: var(--text);
  border-bottom: none;
}
.index-entry:hover {
  background: var(--surface);
  color: var(--text);
}
.index-num {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--muted);
}
.index-name {
  font-size: 18px;
  font-weight: 600;
  color: var(--primary);
}
.index-class {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--accent);
  text-transform: uppercase;
  letter-spacing: 0.04em;
}
.index-meta {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 11px;
  color: var(--muted);
  text-align: right;
}
@media (max-width: 700px) {
  .index-entry { grid-template-columns: 40px 1fr; gap: 12px; padding: 16px 8px; }
  .index-class, .index-meta { grid-column: 2; text-align: left; }
}

/* ---------- Compound Index Entry panel ---------- */
.compound-panel {
  border: 1px solid var(--border-strong);
  background: var(--bg);
  padding: 0;
  margin: 32px 0;
}
.compound-panel-header {
  background: var(--accent);
  color: #fff;
  padding: 10px 18px;
  font-family: 'IBM Plex Mono', monospace;
  font-size: 11px;
  text-transform: uppercase;
  letter-spacing: 0.12em;
  display: flex;
  justify-content: space-between;
  align-items: center;
}
.compound-panel-header .panel-id { color: rgba(255,255,255,0.6); }
.compound-grid {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 0;
}
.compound-cell {
  padding: 14px 18px;
  border-right: 1px solid var(--border);
  border-bottom: 1px solid var(--border);
}
.compound-cell:nth-child(3n) { border-right: none; }
.compound-cell:nth-last-child(-n+3) { border-bottom: none; }
.compound-label {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.1em;
  color: var(--muted);
  margin-bottom: 4px;
}
.compound-value {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 13px;
  color: var(--text);
  font-weight: 500;
  line-height: 1.35;
  word-break: break-word;
}
@media (max-width: 600px) {
  .compound-grid { grid-template-columns: repeat(2, 1fr); }
  .compound-cell:nth-child(3n) { border-right: 1px solid var(--border); }
  .compound-cell:nth-child(2n) { border-right: none; }
  .compound-cell:nth-last-child(-n+3) { border-bottom: 1px solid var(--border); }
  .compound-cell:nth-last-child(-n+2) { border-bottom: none; }
}

/* ---------- Article body ---------- */
.article-meta {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--muted);
  border-top: 1px solid var(--border);
  border-bottom: 1px solid var(--border);
  padding: 10px 0;
  margin: 16px 0 24px;
  display: flex;
  flex-wrap: wrap;
  gap: 18px;
}
.article-meta strong { color: var(--text); font-weight: 500; }

.bluf {
  background: var(--surface);
  border-left: 3px solid var(--primary);
  padding: 18px 22px;
  margin: 24px 0;
  font-size: 16.5px;
  line-height: 1.65;
  color: var(--text);
}
.bluf strong { color: var(--primary); }

/* ---------- Tables ---------- */
.table-wrap {
  overflow-x: auto;
  margin: 24px 0;
  border: 1px solid var(--border);
}
table.comparison-table,
table.data-table {
  width: 100%;
  border-collapse: collapse;
  font-size: 13px;
  background: var(--bg);
}
.comparison-table th,
.data-table th {
  background: var(--surface);
  color: var(--accent);
  font-family: 'IBM Plex Mono', monospace;
  font-size: 10.5px;
  font-weight: 500;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  padding: 11px 12px;
  text-align: left;
  border-bottom: 1.5px solid var(--border-strong);
  white-space: nowrap;
}
.comparison-table td,
.data-table td {
  padding: 11px 12px;
  border-bottom: 1px solid var(--border);
  vertical-align: top;
  color: var(--text);
}
.comparison-table tr:last-child td { border-bottom: none; }
.comparison-table td:first-child { font-family: 'IBM Plex Mono', monospace; color: var(--muted); width: 50px; }

/* ---------- Vendor entries ---------- */
.vendor-entry {
  border-top: 1px solid var(--border);
  padding-top: 32px;
  margin-top: 32px;
}
.vendor-entry:first-of-type { border-top: none; margin-top: 16px; padding-top: 0; }
.vendor-entry h2 {
  display: flex;
  align-items: baseline;
  gap: 12px;
  font-size: 22px;
  color: var(--primary);
}
.vendor-rank {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 14px;
  color: var(--muted);
  background: var(--surface);
  padding: 2px 8px;
  border: 1px solid var(--border);
  font-weight: 400;
}
.vendor-entry .vendor-sub {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--muted);
  margin-bottom: 16px;
  letter-spacing: 0.02em;
}

.key-facts {
  background: var(--surface);
  border: 1px solid var(--border);
  padding: 16px 20px;
  margin: 16px 0;
}
.key-facts ul { margin: 0; padding-left: 18px; font-size: 14px; }
.key-facts li { margin: 4px 0; }
.key-facts li strong { font-family: 'IBM Plex Mono', monospace; font-size: 12px; color: var(--accent); text-transform: uppercase; letter-spacing: 0.04em; }

/* ---------- FAQ accordion ---------- */
details.faq {
  border-bottom: 1px solid var(--border);
  padding: 14px 0;
}
details.faq:first-of-type { border-top: 1px solid var(--border); }
details.faq summary {
  cursor: pointer;
  font-weight: 600;
  font-size: 15px;
  color: var(--text);
  list-style: none;
  display: flex;
  align-items: baseline;
  gap: 12px;
  outline: none;
}
details.faq summary::-webkit-details-marker { display: none; }
details.faq summary::before {
  content: "+";
  font-family: 'IBM Plex Mono', monospace;
  color: var(--primary);
  font-weight: 400;
  font-size: 18px;
  width: 14px;
}
details.faq[open] summary::before { content: "−"; }
details.faq[open] summary { color: var(--primary); margin-bottom: 8px; }
details.faq p { margin: 8px 0 6px 26px; color: var(--text); font-size: 15px; }

/* ---------- Related compound entries ---------- */
.related-block {
  margin-top: 64px;
  padding-top: 28px;
  border-top: 2px solid var(--accent);
}
.related-block .eyebrow { margin-bottom: 18px; }
.related-grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 16px;
}
.related-card {
  border: 1px solid var(--border);
  padding: 16px 18px;
  background: var(--bg);
  border-bottom: 1px solid var(--border);
  color: var(--text);
}
.related-card:hover { background: var(--surface); border-color: var(--border-strong); }
.related-card .related-class {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.1em;
  color: var(--muted);
}
.related-card h4 { color: var(--primary); margin: 4px 0 6px; font-size: 16px; }
.related-card p { margin: 0; font-size: 13px; color: var(--text); }
@media (max-width: 600px) { .related-grid { grid-template-columns: 1fr; } }

/* ---------- Article disclaimer + footer ---------- */
.article-disclaimer {
  margin-top: 48px;
  padding: 14px 18px;
  background: var(--surface);
  border-left: 3px solid var(--muted);
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--muted);
  line-height: 1.6;
}

.author-line {
  font-style: italic;
  color: var(--muted);
  font-size: 14px;
  margin-top: 24px;
  padding-top: 16px;
  border-top: 1px solid var(--border);
}

/* ---------- Cards on home ---------- */
.about-teaser {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 40px;
  border-top: 1px solid var(--border);
  padding-top: 40px;
  margin-top: 56px;
}
.about-teaser h3 { margin-top: 0; }
@media (max-width: 700px) { .about-teaser { grid-template-columns: 1fr; gap: 24px; } }

/* ---------- Site footer ---------- */
.site-footer {
  border-top: 1px solid var(--border);
  background: var(--surface);
  margin-top: 80px;
  padding: 32px 0 28px;
  color: var(--muted);
  font-size: 13px;
}
.site-footer-inner {
  max-width: var(--max-w);
  margin: 0 auto;
  padding: 0 24px;
  display: grid;
  grid-template-columns: 2fr 1fr 1fr;
  gap: 32px;
}
.site-footer h5 {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 11px;
  text-transform: uppercase;
  letter-spacing: 0.1em;
  color: var(--accent);
  margin: 0 0 10px;
  font-weight: 500;
}
.site-footer ul { list-style: none; padding: 0; margin: 0; }
.site-footer li { margin: 5px 0; }
.site-footer a { color: var(--text); border-bottom: none; }
.site-footer a:hover { color: var(--primary); }
.footer-bottom {
  max-width: var(--max-w);
  margin: 28px auto 0;
  padding: 16px 24px 0;
  border-top: 1px solid var(--border);
  font-family: 'IBM Plex Mono', monospace;
  font-size: 11px;
  color: var(--muted);
  display: flex;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 12px;
}
@media (max-width: 700px) {
  .site-footer-inner { grid-template-columns: 1fr; gap: 20px; }
}

/* ---------- Utility ---------- */
.back-link {
  font-family: 'IBM Plex Mono', monospace;
  font-size: 12px;
  color: var(--muted);
  display: inline-block;
  margin-bottom: 16px;
  border-bottom: none;
}
.back-link:hover { color: var(--primary); }
.back-link::before { content: "← "; }

ul, ol { padding-left: 22px; }
li { margin: 4px 0; }

hr { border: none; border-top: 1px solid var(--border); margin: 32px 0; }

/* Structural formula SVG */
.structure-svg {
  display: block;
  margin: 24px auto;
  max-width: 320px;
  color: var(--primary);
}